Radiofrequency thermal balloon angioplasty of vulnerable atherosclerotic plaque accompanied by delta-aminolevulinic acid photodynamic therapy and catheter-based samarium-153 brachytherapy

Abstract Background The balloon angioplasty methods that are currently in use, cause to inflammation and subsequent neoatherosclerosis. Purpose aim of this study was evaluate the effect combined photodynamic therapy brachytherapy on intimal hyperplasia reduction after radiofrequency thermal carotid artery an animal model thin fibrous cap atheromatous plaque, wherein a high resolution diagnostic ultrasound is adjuncted with combination system, goal increased safety. Methods Briefly, New Zealand white rabbits were submitted vulnerable atherosclerotic plaque by primary intravascular injury followed 1.5% cholesterol-rich diet for eight weeks. Histopathology results showed formation advanced atherosclerosis foam cell-rich resulted severe stenosis (>70%) all rabbits' arteries. Then treatment group underwent B-mode ultrasound-guided catheter-based samarium-153 (153Sm, 18 Gy, β particles) photosensitizer delta-aminolevulinic acid (delta-ALA)-mediated fiber optic polarized light-emitting diodes (LEDs) violet light (λ±Δλ = 405±5 nm, E/A 120 J/cm2) therapy. Results from ultrasonography histopathology significant mean value macrophages, lymphocytes, mast cells, cells hyperplastic vascular smooth muscle density compared other groups (p<0.05). Conclusion Apoptotic cytotoxic anti-inflammatory delta-ALA immune can reduce neoatherosclerosis layer. These findings provide basis developing successful clinical application inhibition angioplasty. Funding Acknowledgement Type funding sources: Public Institution(s). Main source(s): Mehrad Research Lab